Clinical trials

117

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Condition / disease
Location
Status: Recruiting

A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.

Participants needed: 530
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 13, 2026Locations: 183
Eligibility criteria

Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-S... [+2]

Participants have already received certain types of treatment for extensive stag... [+2]

Status: Recruiting

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

A study to evaluate the long-term safety of Deucravacitinib versus Ustekinumab in participants with psoriasis

Participants needed: 3,040
Trial details
Phase: Phase 3Age: 40+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 13, 2026Locations: 411
Eligibility criteria

Deemed by the Investigator to be a candidate for phototherapy or systemic treatm... [+7]

Participants must not have recent history of 1 of the following cardiovascular e... [+3]

Status: Not yet recruiting

A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases

The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Sjögren's disease (SjD).

Participants needed: 60
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 14, 2026Locations: 23
Eligibility criteria

SLE participants: Must have diagnosis of SLE defined as fulfilling the 2019 ACR/... [+4]

Participants must not have other systemic immune disorders. Other protocol-defin...

Status: Recruiting

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Participants needed: 500
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 9, 2026Locations: 187
Eligibility criteria

Non-squamous NSCLC, not amenable to treatment in curative intent. [+3]

Inadequate organ function and/or bone marrow reserve. [+3]

Status: Not yet recruiting

A Study to Assess The Safety and Tolerability of Pumitamig-Based Therapy Administered Before Surgery in Participants With Early-Stage Non-Small Cell Lung Cancer (ROSETTA Lung-220)

The purpose of this study is to assess the safety, tolerability, and surgical feasibility of preoperative Pumitamig-based therapy and other molecules in resectable, Early-Stage Non-Small Cell Lung Cancer

Participants needed: 80
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 13, 2026Locations: 50
Eligibility criteria

Participants must have newly diagnosed, previously untreated participants with h... [+2]

Participants must not have unresectable disease, N3 nodal involvement, or any ev... [+7]

Status: Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.

Participants needed: 426
Trial details
Phase: Phase 3Age: 55-90Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 8, 2026Locations: 143
Eligibility criteria

Amyloid PET. [+5]

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease

Participants needed: 586
Trial details
Phase: Phase 3Age: 60-85Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 8, 2026Locations: 128
Eligibility criteria

Participants must have a confirmed diagnosis of Alzheimer's disease (AD), specif... [+3]

Participants must not have any primary psychiatric diagnoses such as major depre... [+3]

Status: Recruiting

A Phase 1 Study of Navlimetostat Tablet Formulations

This study aims to compare the PK of Navlimetostat after administration of a wet-granulation tablet versus the dry-granulation tablet formulation in healthy adult female

Participants needed: 64
Trial details
Phase: Phase 1Age: 18-55Biological sex: FemaleType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 7, 2026Locations: 4
Eligibility criteria

Participants must be healthy adult INOCBP female with no clinically significant... [+2]

Participant must not have any significant acute or chronic medical illness (in t... [+2]

Status: Recruiting

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

The purpose of this study is to evaluate izalontamab brengitecan (iza-bren) combined with osimertinib in participants with previously untreated, locally advanced or metastatic EGFR-mutant NSCLC, compared to osimertinib alone or osimertinib combined with platinum-based chemotherapy

Participants needed: 850
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 8, 2026Locations: 201
Eligibility criteria

Participants must have histologically or cytologically confirmed non-squamous NS... [+3]

Participants must not have unstable, symptomatic, or uncontrolled CNS metastases... [+3]

Status: Recruiting

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

This is an open-label, multicenter Phase 2 study evaluating BMS-986504 in participants with advanced and/or metastatic solid tumors that have MTAP deletion. The study includes a monotherapy component and a combination component in which BMS-986504 is given with other anti-cancer agents. The trial will assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of BMS-986504 alone and in combination regimens.

Participants needed: 260
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 6, 2026Locations: 58
Eligibility criteria

Participant must have histologically confirmed diagnosis of advanced and/or meta... [+4]

Participants must not have prior treatment with a PRMT5 or Methionine adenosyl t... [+5]

Status: Recruiting

Asia Myelodysplastic Syndrome (MDS) Registry

The purpose of this study is to provide a contemporary view and offer invaluable insights into the demographic profiles, clinical characteristics, treatments, and real-world outcomes of individuals with myelodysplastic syndromes (MDS) in Asia.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bristol-Myers SquibbUpdated: Oct 8, 2026Locations: 3Duration: 2 Years
Eligibility criteria

Aged at least 18 years at initial diagnosis of MDS [+5]

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

The purpose of this study is to evaluate the efficacy and safety of KarXT for treatment of Schizophrenia in adolescents.

Participants needed: 166
Trial details
Phase: Phase 3Age: 13-17Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 6, 2026Locations: 37
Eligibility criteria

Diagnosis of schizophrenia as defined by the The Diagnostic and Statistical Manu... [+2]

Any primary DSM-5-TR disorder other than schizophrenia within 12 months before s... [+5]

Status: Recruiting

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

The purpose of this study is to assess BMS-986500 as monotherapy in advanced solid tumors and as combination therapy in CDK4/6 inhibitor pre-treated advanced breast cancer.

Participants needed: 234
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 6, 2026Locations: 21
Eligibility criteria

Participants must be ≥ 18 years of age. [+4]

Participants must not have an active brain metastasis. [+4]

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease

Participants needed: 586
Trial details
Phase: Phase 3Age: 60-85Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 6, 2026Locations: 119
Eligibility criteria

Participants must have a confirmed diagnosis of Alzheimer's disease (AD), specif... [+3]

Participants must not present with any significant or severe medical conditions... [+4]

Status: Recruiting

A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

The purpose of this study is to evaluate the drug levels, efficacy, and safety of Deucravacitinib (BMS-986165) in pediatric participants with juvenile psoriatic arthritis.

Participants needed: 60
Trial details
Phase: Phase 3Age: 5-17Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 6, 2026Locations: 48
Eligibility criteria

Participants must have been diagnosed with Juvenile Psoriatic Arthritis (JPsA). [+2]

Participants must not have been diagnosed with JPsA before 5 years of age. [+3]

Status: Recruiting

A Study of Navlimetostat (BMS-986504) Drug Interactions and Food Effect in Healthy Participants

The purpose of this study is to assess the food effect and drug interactions on drug levels of Navlimetostat in health adult female participants

Participants needed: 80
Trial details
Phase: Phase 1Age: 18-55Biological sex: FemaleType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 5, 2026Locations: 1
Eligibility criteria

Participants must be healthy adult female (as assigned at birth) individuals not... [+1]

Participants must not have any significant acute or chronic medical illness (in... [+3]

Status: Recruiting

A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis

The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis

Participants needed: 46
Trial details
Phase: Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 1, 2026Locations: 9
Eligibility criteria

Participants with Rheumatoid Arthritis must have onset after age 18. [+3]

Participants must not have any significant medical condition, with the exception... [+3]

Status: Recruiting

A Study to Assess Deucravacitinib Safety in Pregnancy

The purpose of this study is to assess pregnancy and infant outcomes among pregnant participants enrolled in an established North American pregnancy registry (Organization of Teratology Information Specialists \[OTIS\]) who were exposed to deucravacitinib.

Participants needed: 900
Trial details
Biological sex: FemaleType: ObservationalSponsor: Bristol-Myers SquibbUpdated: Oct 1, 2026Locations: 1
Eligibility criteria

Currently pregnant during the enrollment period [+9]

Pregnant women who have enrolled in this cohort study with a previous pregnancy [+17]

Status: Recruiting

A Study to Evaluate the Long-Term Safety of Idecabtagene Vicleucel Treatment in Adults With Newly Diagnosed Multiple Myeloma in Korea

The purpose of this study is to monitor the long-term safety of participants who received idecabtagene vicleucel treatment as part of the KarMMa-9 (CA089-1043) Phase 3 clinical trial.

Participants needed: 15
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bristol-Myers SquibbUpdated: Oct 1, 2026Locations: 5
Eligibility criteria

Adult participants ≥19 years of age [+2]

Participants who participate in KarMMa-9 trial (CA089-1043) but disagree with lo... [+1]

Status: Recruiting

A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

The purpose of this study is to assess the safety, tolerability, and efficacy of Imzokitug in combination with Pumitamig and Platinum-Doublet Chemotherapy (PDCT) versus Pumitamig and PDCT as first-line treatment for participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Participants needed: 160
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Oct 2, 2026Locations: 73
Eligibility criteria

Participants must have histologically confirmed diagnosis of stage IV non-small... [+4]

Participants must not have any documented actionable genomic alterations (AGAs)... [+3]

Status: Not yet recruiting

Repotrectinib Post-Marketing Surveillance in Korean Patients With ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) or Solid Tumors Harboring a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion

This observational study evaluates the real-world safety and effectiveness of repotrectinib in Korean participants with locally advanced or metastatic ROS1-positive non-small cell lung cancer or solid tumors harboring neurotrophic tyrosine receptor kinase (NTRK) gene fusions. Participants receiving repotrectinib in routine clinical practice will be followed for up to 12 months or until the end of the 2-year surveillance period, whichever occurs first.

Participants needed: 10
Trial details
Age: 12+Biological sex: AllType: ObservationalSponsor: Bristol-Myers SquibbUpdated: Sep 30, 2026Locations: 1
Eligibility criteria

Participants aged ≥19 years with histologically OR cytologically confirmed local... [+3]

Treatment with repotrectinib for indications not approved in Korea [+2]

Status: Recruiting

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

The purpose of this study is to evaluate the efficacy of Pumitamig versus Pembrolizumab in participants with previously untreated advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%.

Participants needed: 750
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Sep 30, 2026Locations: 284
Eligibility criteria

Participants must have a histologically or cytologically confirmed diagnosis of... [+4]

Participants must not have any documented actionable genomic alteration (AGA) fo... [+4]

Status: Recruiting

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

A study to evaluate Pumitamig versus Durvalumab following concurrent chemoradiation therapy in participants with unresectable stage III Non-small Cell Lung Cancer (NSCLC)

Participants needed: 850
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Sep 30, 2026Locations: 260
Eligibility criteria

Participants must have a histologically- or cytologically-confirmed diagnoses of... [+3]

Participants with non-squamous histology must not have documented Epidermal Grow... [+5]

Status: Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

The purpose of this study is to evaluate the safety and efficacy of Pumitamig in combination with chemotherapy versus Nivolumab in combination with chemotherapy in participants with previously untreated advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma

Participants needed: 690
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Bristol-Myers SquibbUpdated: Sep 30, 2026Locations: 161
Eligibility criteria

Participants must be previously untreated with systemic treatment for advanced/m... [+3]

Participants must not have untreated known central nervous system (CNS) metastas... [+6]

Status: Recruiting

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

The purpose of this study is to understand treatment preference and satisfaction among adults with schizophrenia in the United States who are prescribed xanomeline and trospium chloride (X/T) therapy

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bristol-Myers SquibbUpdated: Sep 30, 2026Locations: 20
Eligibility criteria

Aged ≥18 years at index date. [+5]

Participation in an interventional study within the last 30 days or plan to part... [+1]