Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial

With this trial, the aim is to assess the benefits and harms of a non-surgical intensive weight loss intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with bariatric surgery for people with severe and complex obesity. The interpretation of the results will help inform future care pathways for people with obesity in whom bariatric surgery is currently the only available effective treatment option.

Participants needed: 500
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Carsten DirksenUpdated: Aug 21, 2026Locations: 14
Eligibility criteria

Aged 18 to 60 years (inclusive) at time of screening. [+4]

Prior bariatric or hiatal surgery, not including intragastric balloons or duoden... [+10]

Read more
Status: Recruiting

Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity

In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with severe and complex obesity.

Participants needed: 600
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Carsten DirksenUpdated: Dec 1, 2025Locations: 14
Eligibility criteria

Age ≥18 years and ≤60 years old at screening. [+2]

Intending to become pregnant in the next two years or pregnant or breastfeeding. [+9]

Read more