Health TrialsbyHealthPanel

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Descartes-08 in Autoantibody Myositis

This is a randomized, double-blind, placebo-controlled phase 2 study to evaluate the efficacy, safety and tolerability of an autologous T-cells expressing a chimeric antigen receptor (CAR) directed to B-Cell maturation antigen (BCMA) in patients with autoantibody-mediated myositis, including antisynthetase syndrome (ASyS) and dermatomyositis (DM).

Participants needed: 60
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Cartesian TherapeuticsUpdated: Aug 17, 2026Locations: 4
Eligibility criteria

Participants must have dermatomyositis or antisynthetase syndrome with muscle an... [+4]

Isolated interstitial lung disease (ILD) without muscle or skin involvement [+10]

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Status: Recruiting

Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders

Safety, tolerability and efficacy of Descarte-08 in children, adolescents and young adults with childhood-onset systemic lupus erythematosus, ANCA-associated vasculitis, juvenile myasthenia gravis, and juvenile dermatomyositis

Participants needed: 50
Trial details
Phase: Phase 1, Phase 2Age: 12+Biological sex: AllType: InterventionalSponsor: Cartesian TherapeuticsUpdated: Jul 27, 2026Locations: 3
Eligibility criteria

At least age 12 [+4]

Major chronic illness that is not well managed at the time of study entry and in... [+12]

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