Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib (arm is currently closed to accrual) * Temozolomide (temodar) * Neratinib (arm is currently closed to accrual) * CC115 (arm is currently closed to accrual) * QBS10072S

Participants needed: 460
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: David Reardon, MDUpdated: Aug 19, 2026Locations: 12
Eligibility criteria

Participants must have histologically confirmed intracranial glioblastoma or gli... [+25]

Participants will not be eligible if the original diagnosis was a lower grade gl... [+27]

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Status: Recruiting

CUE-102 in Recurrent Glioblastoma

The goal of this study is to evaluate the safety of the experimental drug, CUE-102, and establish the recommended dose of CUE-102 for participants with Recurrent Glioblastoma (GBM). The name of the study drug involved in this study is: -CUE-102 (a type of fusion protein)

Participants needed: 18
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: David Reardon, MDUpdated: Mar 5, 2026Locations: 2
Eligibility criteria

Have HLA-A*0201 genotype as determined by genomic testing performed locally; [+51]

Received any therapy for tumor recurrence other than surgery; [+34]

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