Clinical trials

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Condition / disease
Location
Status: Recruiting

IMMUNOPLANT for Newly Diagnosed Multiple Myeloma

The purpose of this study is to determine whether Linvoseltamab therapy in patients with newly diagnosed multiple myeloma will convert the disease status from minimal residual disease (MRD)-positive to MRD-negative, and increase the length of time that the disease is controlled. The researchers also want to find out the effects (good and bad) that Linvoseltamab has on participants and the condition.

Participants needed: 150
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Dickran Kazandjian, MDUpdated: Aug 18, 2026Locations: 1
Eligibility criteria

Diagnosis of newly-diagnosed multiple myeloma (NDMM) per International Myeloma W... [+13]

Patients who have received prior systemic therapies for MM other than initial IM... [+25]

Status: Recruiting

Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse

The purpose of this study is to determine whether giving linvoseltamab with lenalidomide during maintenance treatment to participants with multiple myeloma will: 1. Get rid of any residual multiple myeloma cells in participants' bodies which is known as minimal residual disease negative (MRD-) status. For participants that start the study with residual multiple myeloma cells in participants' bodies: to determine how long you remain MRD-. 2. Increase the length of time that participants' disease is controlled. For participants with relapsed disease, to determine whether participants can re-attain MRD- status. 3. Increase the length of time that participants' disease responds to treatment. The researchers also want to find out the effects that linvoseltamab has on participants and participants' condition.

Participants needed: 32
Trial details
Phase: Phase 2Biological sex: AllType: InterventionalSponsor: Dickran Kazandjian, MDUpdated: Jan 8, 2026Locations: 1
Eligibility criteria

Diagnosis of newly-diagnosed multiple myeloma (NDMM) per International Myeloma W... [+15]

Patients who have received prior systemic therapies for Multiple Myeloma (MM) ot... [+19]