Status: Recruiting
Oncolytic Virotherapy to Enhance PReoperative IMmunotherapy Efficacy in Patients With Proficient Mismatch Repair (pMMR) Rectal Cancer
A Phase I clinical trial that will investigate the safety and tolerability of combining the modified vaccinia virus BT-001 with systemic pembrolizumab in patients with localised pMMR rectal cancer
Participants needed: 20
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Henry SmithUpdated: Jul 10, 2026Locations: 1
Eligibility criteria
Histological diagnosis of primary, localised rectal adenocarcinoma (cT2N0M0 to c... [+13]
Have impending bowel obstruction or other indications for acute surgical interve... [+13]