Clinical trials

1

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

CnF-DBS for Levodopa-Resistant FOG

The purpose of this trial is to study the safety, practicality, and effectiveness of deep brain stimulation (DBS) therapy in a brain region called the cuneiform nucleus (CnF) to treat disabling freezing of gait (FOG) in patients with Parkinson's disease (PD) when standard treatments are no longer effective. The study uses either the Medtronic's Percept™ PC or RC systems for DBS therapy. Please note that although the Medtronic systems are FDA-approved for other diseases, they have not been approved for the treatment of FOG in PD and their use for stimulation of the CnF target is experimental.

Participants needed: 18
Trial details
Age: 35-80Biological sex: AllType: InterventionalSponsor: Iahn CajigasUpdated: Aug 24, 2026Locations: 3
Eligibility criteria

Age between 35 and 80 years [+10]

Major executive dysfunction or dementia (DRS-2 ≤ 130) or other neurocognitive im... [+9]