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Condition / disease
Location
Status: Not yet recruiting

Glofitamab in B-NHL Using Mid-Therapy Intratumoral Transcriptomics

This trial will enroll patients with relapsed/refractory DLBCL and MCL, with the opportunity to receive single-agent glofitamab as early as the second-line. Patients will have superficially accessible disease to enable core-needle biopsy prior to therapy initiation, and on cycle 1 day 15 and cycle 2 day 1 of therapy administration to enable high throughput molecular profiling of disease and immune dynamics while on treatment.

Participants needed: 16
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Joshua BrodyUpdated: Aug 5, 2026Locations: 1
Eligibility criteria

Patients with pathologically confirmed diagnosis of aggressive CD20(+) B-NHL, [+7]

Contraindication to any of the individual components of glofitamab or history of... [+41]