Health Trials

Clinical trials

2

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Condition / disease
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Status: Not yet recruiting

An Open-Label PET/CT Imaging Study to Evaluate Brain Serotonin Transporter (SERT) Occupancy Following Single-Dose Administration of LG-0317 Tablets in Healthy Participants

The purpose of the study is to evaluate brain serotonin transporter (SERT) receptor occupancy (RO) following single oral doses of LG-0317 tablets in healthy male participants; and to explore the pharmacokinetic/pharmacodynamic (PK/PD) relationship between LG-0317 plasma concentrations and SERT occupancy..

Participants needed: 12
Trial details
Phase: Phase 1Age: 18-45Biological sex: MaleType: InterventionalSponsor: LinGang LaboratoryUpdated: Jul 16, 2026
Eligibility criteria

Participant must weigh at least 50 kg to participate in the study, and must have... [+3]

1) Allergic constitution, history of allergic diseases, or known allergy to the...

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Status: Recruiting

A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LG-0317 in Healthy Participants

This study is the first administration of LG-0317 to humans. The purpose of the study is to evaluate safety/tolerability and pharmacokinetics in healthy subjects. The intention of this study is to provide confidence in the safety of the molecule to inform progression to further proof-of-concept studies.

Participants needed: 100
Trial details
Phase: Phase 1Age: 18-45Biological sex: AllType: InterventionalSponsor: LinGang LaboratoryUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

Healthy male and female subjects age 18 to 45 years of age included. [+4]

History of allergic diseases, or known allergy to the investigational product, i... [+10]

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