Health Trials

Clinical trials

4

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Condition / disease
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Status: Not yet recruiting

An Open Label, Single Treatment, Single Arm, Multiple Dose Phase-2 Study to Evaluate the Pharmacokinetics, Safety, and Clinical Performance of EscharEx (EX-03) in Participants With Venous Leg Ulcers

This is a pharmacokinetics (PK) study - the main objective of this study is to assess the PK, safety and clinical performance of 5% EscharEx (EX-03 formulation) in debridement of Venous Leg Ulcers

Participants needed: 20
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: MediWound LtdUpdated: Jul 9, 2026
Eligibility criteria

Men or women, older than 18 years of age, [+5]

Wound size that has decreased by > 20% after 7 (+3/-1) days of the screening per... [+24]

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Status: Recruiting

A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)

The main objective of this study is: To assess the efficacy and safety of EscharEx (EX-03 5% formulation) compared to placebo control,in debridement and wound bed preparation of Venous Leg Ulcers (VLU).

Participants needed: 216
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: MediWound LtdUpdated: Apr 2, 2026Locations: 25
Eligibility criteria

Men or women, older than 18 years of age, [+5]

Wound size that has decreased by > 20% after 7 (+3/-1) days of the screening per... [+24]

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Status: Not yet recruiting

Clinical Study to Evaluate the Safety and the Efficacy of EscharEx Drug Product (EX-03 Formulation) and Its Placebo Compared to Collagenase, Non-surgical Standard of Care, in Patients With Venous Leg Ulcers

The main objective of this study is: To assess the safety of EscharEx (EX-03 5% formulation) compared to placebo control and compared to Collagenase (NSSOC) in patients with VLU.

Participants needed: 45
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: MediWound LtdUpdated: Nov 15, 2024Locations: 2
Eligibility criteria

Men or women, older than 18 years of age, [+5]

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Status: Recruiting

A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma

This study will be a multicenter, prospective, open label, one-arm study intended to assess the Safety and Efficacy of EscharEx (EX-02) in the treatment of Basal Cell Carcinoma. In patients with one primary superficial or nodular basal cell carcinoma lesion with a diameter of 5-10mm (Histologically confirmed BCC) located on the trunk or upper extremities (not including the hands), with well-defined borders and no previous radiation therapy.

Participants needed: 32
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: MediWound LtdUpdated: Dec 15, 2021Locations: 3
Eligibility criteria

Male or female greater than age 18, [+4]

Evidence of Gorlin syndrome, neoplastic diseases (except actinic lesions), metas... [+11]

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