Clinical trials

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Condition / disease
Location
Status: Recruiting

A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury

The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291. The main questions it aims to answer are: * Does NVG-291 improve hand function and daily activities? * What side effects do participants have when taking NVG-291? Researchers will compare NVG-291 to a placebo (a look-alike substance that does not contain NVG-291) to see if NVG-291 improves function in adults with chronic cervical motor-incomplete spinal cord injury. Participants will: * Take NVG-291 or a placebo by injection under the skin (subcutaneous) once daily for 12 weeks. * Attend clinic visits for checkups and safety tests. * Complete tests and questionnaires about hand function, walking, daily activities, and quality of life. * Take part in an interview about changes in their condition, within 14 days after the Week 12 visit.

Participants needed: 150
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: NervGen PharmaUpdated: Oct 5, 2026Locations: 18
Eligibility criteria

Provide written informed consent prior to any study-specific procedures. [+8]

Nontraumatic spinal cord injury, penetrating spinal cord injury, multiple noncon... [+18]