Clinical trials

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Condition / disease
Location
Status: Recruiting

OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity

The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions. It will also learn about the safety of Phentolamine Ophthalmic Solution. The main questions it aims to answer are: Researchers will compare Phentolamine Ophthalmic Solution to a placebo (a look-alike substance that contains no drug) to see if Phentolamine Ophthalmic Solution works to improve vision in low light conditions. Participants will: Take Phentolamine Ophthalmic Solution or a placebo drop every day for 2 weeks Visit the clinic once every week for 2 weeks for checkups and tests Keep a diary of when they instill the study medication each evening

Participants needed: 580
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Ocuphire Pharma, Inc.Updated: Sep 8, 2026Locations: 20
Eligibility criteria

Males or females ≥ 18 years of age [+7]

Prior unresolved dry eye diagnosis, taking prescription medication for dry eye (... [+22]