Health TrialsbyHealthPanel

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

This is a first-in-human, open-label, multicenter phase 1 study to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of OP-3136, a lysine acetyltransferases 6A and 6B (KAT6A/B) inhibitor, as monotherapy and in combination with other anticancer agents in participants with advanced solid tumors. This study consists of 2 parts: a dose escalation part (Part 1) and dose expansion part (Part 2).

Participants needed: 180
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Olema Pharmaceuticals, Inc.Updated: Oct 5, 2026Locations: 25
Eligibility criteria

Participants with advanced or metastatic ER+HER2- breast cancer, mCRPC, or NSCLC... [+6]

Prior therapy with KAT6A/B inhibitor in any treatment setting. [+4]

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Status: Recruiting

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

This phase 3 clinical trial compares the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received prior systemic anti-cancer treatment for advanced breast cancer.

Participants needed: 1,000
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Olema Pharmaceuticals, Inc.Updated: Sep 23, 2026Locations: 200
Eligibility criteria

Adult female or male participants. [+7]

Disease recurrence during adjuvant endocrine therapy [+5]

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