Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Evaluate Single and Multiple Doses of TLC-1180 in Healthy Subjects

This phase 1 study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of TLC-1180 after single- and multiple-ascending doses in healthy subjects.

Participants needed: 332
Trial details
Phase: Phase 1Age: 18-55Biological sex: AllType: InterventionalSponsor: OrsoBio, IncUpdated: Aug 21, 2026Locations: 1
Eligibility criteria

Non-smoking, healthy male or female subject between 18 and 55 years of age, incl... [+8]

Pregnant or lactating subjects [+17]

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Status: Recruiting

Phase 2a Study of Safety, Tolerability, and Efficacy of TLC-2716 in Subjects With Hypertriglyceridemia and NAFLD

This is a Phase 2a, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, and efficacy of 2 dose levels of TLC-2716 in subjects with hypertriglyceridemia and nonalcoholic fatty liver disease as assessed by changes in fasting triglycerides, liver steatosis by MRI, and other biomarkers.

Participants needed: 30
Trial details
Phase: Phase 2Age: 18-70Biological sex: AllType: InterventionalSponsor: OrsoBio, IncUpdated: Apr 3, 2025Locations: 4
Eligibility criteria

BMI ≥ 28 kg/m2 at Screening [+8]

HbA1c ≥ 9.5% at Screening [+18]

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