Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

Virtual Reality for Vocational Recovery

Unemployment is higher among young people who experience mental ill-health compared to the general population. This can have a lasting impact on young people, many of whom are highly motivated to gain employment and education. There are many challenges to seeking, gaining, and maintaining employment for young people. To address these challenges and help young people meet their employment and education goals, investigators have developed a VR intervention to support vocational skill building. The aim of the current study is to evaluate the feasibility, acceptability, and safety, of the Virtual Reality for Vocational Recovery (VR4VR) intervention. A small group of vocational specialists will support up to 20 young people with their vocational outcomes using VR4VR over a 3-6week period. Both young people and specialists will complete questionnaires related to acceptability of the intervention, including qualitative interviews. Data on feasibility and safety will also be collected. Results will inform whether VR is feasible, acceptable, and safe to support vocational outcomes within vocational services that support young people with mental health difficulties, potentially supporting further intervention development and larger trials.

Participants needed: 20
Trial details
Age: 18-25Biological sex: AllType: InterventionalSponsor: OrygenUpdated: Aug 11, 2025Locations: 3
Eligibility criteria

They are aged 18-25 seeking vocational support at participating vocational suppo... [+3]

They lack fluency in English (spoken and written), since this is required to und... [+9]

Status: Recruiting

Guanfacine Extended-release for Adolescents With Cannabis Use

A randomized controlled trial to assess the efficacy of extended-release guanfacine to reduce cannabis use frequency in young people with cannabis use disorder following a period of monitored abstinence.

Participants needed: 100
Trial details
Phase: Phase 2Age: 12-25Biological sex: AllType: InterventionalSponsor: OrygenUpdated: Jul 31, 2025Locations: 1
Eligibility criteria

12-25 years of age (inclusive) at consent; [+4]

DSM-5 substance use disorder (moderate or severe) except cannabis or nicotine; [+8]