Health TrialsbyHealthPanel

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

First-in-Human Safety and Tolerability Study of OPF-110 in Healthy Adults

This study will evaluate the safety and tolerability of OPF-110 in healthy adult participants.

Participants needed: 24
Trial details
Phase: Phase 1Age: 18-64Biological sex: AllType: InterventionalSponsor: Otsuka Pharmaceutical Factory, Inc.Updated: Sep 30, 2026Locations: 1
Eligibility criteria

Capable of giving signed informed consent , which includes compliance with the r... [+7]

Participants who have hypertriglyceridemia (serum triglyceride levels of >150 mg... [+12]

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Status: Recruiting

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 Diabetes Mellitus (T1DM) and a level 3 (severe) hypoglycemic episode at least three times within the 1 year prior to enrollment despite treatment with a closed loop system (CLS) for at least 6 months.

Participants needed: 13
Trial details
Phase: Phase 1, Phase 2Age: 35-70Biological sex: AllType: InterventionalSponsor: Otsuka Pharmaceutical Factory, Inc.Updated: Aug 21, 2026Locations: 1
Eligibility criteria

Subject must be aged 35 to 70 years of age inclusive, at the time of signing the... [+11]

Previous history of insulin resistance (defined as an average insulin dose requi... [+32]

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