Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0253 in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutated advanced solid tumors as monotherapy.

Participants needed: 240
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: PAQ Therapeutics, Inc.Updated: Aug 12, 2026Locations: 15
Eligibility criteria

Histologically or cytologically confirmed advanced or metastatic solid malignanc... [+4]

Active brain metastasis or carcinomatous meningitis. If participants have had br... [+19]

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Status: Recruiting

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0511 in adult participants with solid tumors as monotherapy and in combination with cetuximab in participants with colorectal cancer (CRC).

Participants needed: 210
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: PAQ Therapeutics, Inc.Updated: Jul 6, 2026Locations: 9
Eligibility criteria

Men or women less than or equal to (>=) 18 years of age [+6]

Active brain metastasis or carcinomatous meningitis. If participants have had br... [+22]

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