Status: Recruiting
Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
This prospective study aims to characterize blood brain barrier (BBB) disruption in patients with newly diagnosed glioblastoma multiforme undergoing surgical resection. The study integrates advanced MRI, circulating BBB biomarkers, neurocognitive assessment, and molecular analysis of tumor tissue to investigate relationships between BBB integrity, tumor biology, and neurological function. Participants will undergo serial assessments before surgery, after surgery, and following radiotherapy. Tumor tissue collected during standard-of-care resection will undergo immunohistochemical and transcriptional
Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Patrick MorrisUpdated: Jul 28, 2026Locations: 1
Eligibility criteria
Adult patients aged 18 years or older. [+4]
Contraindication to magnetic resonance imaging. [+2]