Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)

The goal of this clinical study is to compare ulixacaltamide and placebo treatment in essential tremor. The main question it aims to answer is: • Is ulixacaltamide a safe and efficacious treatment for patients with essential tremor? Participants will be asked to participate in one of two clinical studies where they will be treated with either ulixacaltamide or placebo for a period of up to 12 weeks. After the controlled study completion, they will be eligible to participate in a long-term, open-label safety study (LTSS) and be treated with ulixacaltamide. Participants are eligible to enroll directly into the LTSS if they previously participated in an essential tremor trial, received sponsor invitation after being deemed ineligible for the controlled study, or following enrollment closure of the controlled study.

Participants needed: 1,000
Trial details
Phase: Phase 3Age: 18-85Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Oct 6, 2026Locations: 1
Eligibility criteria

Has a body mass index (BMI) at Screening of ≥18 kg/m2. [+6]

Neuropathy, muscle weakness, arthropathy or other musculoskeletal diagnosis of t... [+45]

Status: Recruiting

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

A Multi-Center, Single-Arm Clinical Trial to Investigate the Efficacy and Safety of Elsunersen in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy

Participants needed: 40
Trial details
Phase: Phase 3Age: 1-18Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Aug 3, 2026Locations: 10
Eligibility criteria

Has a documented Gain of Function SCN2A variant confirmed through genetic testin... [+2]

Has any clinically significant or known pathogenic genetic variant other than in... [+3]

Status: Recruiting

An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures

An Open Label Clinical Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adult Patients With Focal Onset or Primary Generalized Tonic-Clonic Seizures

Participants needed: 50
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Apr 3, 2025Locations: 11
Eligibility criteria

A diagnosis of focal onset seizures or idiopathic generalized tonic clonic seizu... [+3]

History of pseudo or psychogenic seizures, or cluster seizures only, within the... [+10]