Clinical trials

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Condition / disease
Location
Status: Recruiting

To Evaluate the Safety and Efficacy of RP902 Tablets

The purpose of the study is to evaluate the preliminary efficacy of RP902 Tablets in participants with Alzheimer's disease (AD)-derived mild cognitive impairment (MCI) and provide a design basis for the Phase III study. This Phase II study plans to enroll 360 participants and will be conducted at approximately 50 sites in China. The study consists of a Screening Period (up to 4 weeks) and a double-blind treatment period (48 weeks). After completing the 48-week double-blind treatment period, participants may choose to continue into an extension treatment period (96 weeks) or undergo safety follow-up (4 weeks after the last dose).

Participants needed: 360
Trial details
Phase: Phase 2Age: 50-85Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Oct 1, 2026Locations: 2
Eligibility criteria

Voluntary participation and signed informed consent form. [+5]

Dementia caused by other etiologies. [+13]

Status: Recruiting

A Randomised, Open-label, Multicentre Phase III Clinical Study to Evaluate the Efficacy and Safety of JS105 Combined With Dalpiciclib and Fulvestrant Compared With Dalpiciclib and Fulvestrant in Patients With PIK3CA-mutated, HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer.

This study is a randomised, open-label, multicentre phase III clinical study evaluating the efficacy and safety of JS105 combined with Dalpiciclib and Fulvestrant compared with Dalpiciclib and Fulvestrant in patients with PIK3CA-mutated, HR-positive, HER2-negative recurrent or metastatic breast cancer.

Participants needed: 312
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Dec 30, 2025Locations: 2
Eligibility criteria

At the time of signing the consent form, age must be between 18 and 75 years old... [+7]

Previously treated with fulvestrant or PI3K/AKT/mTOR inhibitors; [+11]

Status: Recruiting

A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors

This study is an open-label, multicenter, Phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of JS105 in combination with other anti-tumor therapies in patients with advanced solid tumors. Patients will be enrolled in two stages: a dose-escalation stage and a dose-expansion stage.

Participants needed: 306
Trial details
Phase: Phase 1, Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Jul 25, 2025Locations: 1
Eligibility criteria

Understand and voluntarily sign the informed consent form; [+18]

At least one measurable lesion (only for Phase II cohort expansion phase) or non... [+11]