Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

To Evaluate the Safety and Efficacy of RP902 Tablets

The purpose of the study is to evaluate the preliminary efficacy of RP902 Tablets in participants with Alzheimer's disease (AD)-derived mild cognitive impairment (MCI) and provide a design basis for the Phase III study. This Phase II study plans to enroll 360 participants and will be conducted at approximately 50 sites in China. The study consists of a Screening Period (up to 4 weeks) and a double-blind treatment period (48 weeks). After completing the 48-week double-blind treatment period, participants may choose to continue into an extension treatment period (96 weeks) or undergo safety follow-up (4 weeks after the last dose).

Participants needed: 360
Trial details
Phase: Phase 2Age: 50-85Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Aug 3, 2026
Eligibility criteria

Voluntary participation and signed informed consent form. [+5]

Dementia caused by other etiologies. [+13]

Status: Recruiting

A Randomised, Open-label, Multicentre Phase III Clinical Study to Evaluate the Efficacy and Safety of JS105 Combined With Dalpiciclib and Fulvestrant Compared With Dalpiciclib and Fulvestrant in Patients With PIK3CA-mutated, HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer.

This study is a randomised, open-label, multicentre phase III clinical study evaluating the efficacy and safety of JS105 combined with Dalpiciclib and Fulvestrant compared with Dalpiciclib and Fulvestrant in patients with PIK3CA-mutated, HR-positive, HER2-negative recurrent or metastatic breast cancer.

Participants needed: 312
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Dec 30, 2025Locations: 2
Eligibility criteria

At the time of signing the consent form, age must be between 18 and 75 years old... [+7]

Previously treated with fulvestrant or PI3K/AKT/mTOR inhibitors; [+11]

Status: Recruiting

A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors

This study is an open-label, multicenter, Phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of JS105 in combination with other anti-tumor therapies in patients with advanced solid tumors. Patients will be enrolled in two stages: a dose-escalation stage and a dose-expansion stage.

Participants needed: 306
Trial details
Phase: Phase 1, Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Risen (Suzhou) Pharma Tech Co., Ltd.Updated: Jul 25, 2025Locations: 1
Eligibility criteria

Understand and voluntarily sign the informed consent form; [+18]

At least one measurable lesion (only for Phase II cohort expansion phase) or non... [+11]