Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

Study to Assess Linsitinib in Participants With Moderate to Severe Active Thyroid Eye Disease (TED)

The goal of this clinical trial is to evaluate the efficacy, safety, and tolerability of linsitinib in participants with moderate to severe Thyroid Eye Disease (TED).

Participants needed: 130
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Sling Therapeutics, Inc.Updated: Aug 11, 2026Locations: 1
Eligibility criteria

Participants must be ≥ 18 years of age at Screening [+4]

Any progressing optic neuropathy due to TED that has worsened in the last 6 mont... [+4]

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Status: Recruiting

Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

The overall study objective is to continue to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of linsitinib in subjects who were enrolled in the prior VGN-TED-301 through Week 24. These subjects include VGN-TED-301 Week 24 proptosis non-responders or subjects who relapse during the Follow-Up Period of VGN-TED-301.

Participants needed: 75
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Sling Therapeutics, Inc.Updated: Feb 25, 2025Locations: 2
Eligibility criteria

Subject who completed the 24-week double-mask period of VGN-TED-301 and are prop... [+3]

The exclusion criteria of protocol VGN-TED-301 also apply to this extension stud...

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