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Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) maintenance treatment.

Participants needed: 645
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Spyre Therapeutics, Inc.Updated: Oct 6, 2026Locations: 273
Eligibility criteria

Diagnosis of UC for ≥3 months before Day 1, confirmed by endoscopy and histology... [+2]

Current diagnosis of Crohn's disease or Inflammatory Bowel Disease (IBD)-Undefin... [+2]

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Status: Not yet recruiting

A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)

This Phase 2 study will test whether the investigational medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced standard of care treatment. About 150 participants will be assigned by chance to receive either SPY072 or placebo for 16 weeks. Participants will be followed after the treatment period to evaluate safety and how long treatment effects may last.

Participants needed: 150
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Spyre Therapeutics, Inc.Updated: Aug 14, 2026Locations: 12
Eligibility criteria

Clinical diagnosis of Hidradenitis Suppurativa with symptoms for at least 6 mont... [+3]

More than 20 draining tunnels at screening or Day 1. [+2]

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