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Clinical trials

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Condition / disease
Location
Status: Recruiting

Phase 2 Study of SR-8541A in Combination With Botensilimab and Balstilimab in Subjects With Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC)

This is an open-label, dose escalation and expansion, multi-center phase 2 study evaluating the safety and efficacy of SR-8541A administered orally in combination with intravenous botensilimab and balstilimab in subjects with MSS-CRC with and without active liver metastases.

Participants needed: 70
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Stingray TherapeuticsUpdated: Aug 12, 2026Locations: 6
Eligibility criteria

Written informed consent from subject [+13]

Hypersensitivity or allergy to any of the study drugs or their excipients. [+33]

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Status: Recruiting

A Study of SR-8541A (ENPPI Inhibitor) in Advanced/Metastatic Solid Tumors

This is an open-label, dose-escalation, multi-center phase 1 study evaluating the safety, tolerability, and pharmacokinetics (PK) of SR-8541A administered orally as a monotherapy or in combination with an immune checkpoint inhibitor (ICI) in subjects with solid tumors.

Participants needed: 25
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Stingray TherapeuticsUpdated: Jun 8, 2025Locations: 3
Eligibility criteria

Life expectancy of at least 3 months [+5]

Primary central nervous system (CNS) tumor [+17]

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