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Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)

Participants needed: 600
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Summit TherapeuticsUpdated: Oct 6, 2026Locations: 236
Eligibility criteria

ECOG performance status score of 0 or 1 [+4]

Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) dise... [+6]

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Status: Recruiting

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.

Participants needed: 780
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Summit TherapeuticsUpdated: Sep 18, 2026Locations: 285
Eligibility criteria

Age ≥ 18 years old at the time of enrollment [+7]

Histologic or cytopathologic evidence of the presence of small cell lung carcino... [+10]

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Status: Recruiting

A Study of Ivonescimab in Combination With Enfortumab Vedotin vs Pembrolizumab in Combination With Enfortumab Vedotin in Metastatic Urothelial Carcinoma

A Randomized, Open-Label, Multicenter, Phase 2/3 Clinical Study of Ivonescimab in Combination with Enfortumab Vedotin vs Pembrolizumab in Combination with Enfortumab Vedotin in Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma (HARMONi-GU1)

Participants needed: 800
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Summit TherapeuticsUpdated: Sep 11, 2026Locations: 7
Eligibility criteria

18 years and older [+6]

Locally advanced disease that is resectable or suitable for local therapy with c... [+4]

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