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Clinical trials

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Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Optimal Anti-Thrombotic Management Following Percutaneous Left Atrial Appendage Occlusion

This randomized study was designed to compare two antithrombotic regimens (long-term half-dose apixaban vs long-term aspirin after 45-days of full-dose apixaban) after successful Watchman implantation.

Participants needed: 234
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Texas Cardiac Arrhythmia Research FoundationUpdated: Oct 5, 2026Locations: 1
Eligibility criteria

• Men and women ≥18 years of age; [+3]

Two or more clinical characteristics at baseline (age≥80 years, body weight ≤60... [+13]

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Status: Recruiting

Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF

Earlier studies have shown a dose-dependent relationship between alcohol intake and incident atrial fibrillation (AF) as well as a causal link with several risk factors for AF such as hypertension, obesity and sleep apnea. However, the effect of drinking (alcohol) on post-ablation outcome such as arrhythmia recurrence, quality of life (QoL) and cognitive function in AF patients is unclear. Therefore, we aim to find the answer for a very frequently asked question, "is it safe to continue drinking alcohol (at the pre-ablation level) following catheter ablation OR should the intake be reduced for better outcome?", in this randomized trial.

Participants needed: 184
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: Texas Cardiac Arrhythmia Research FoundationUpdated: Sep 14, 2026Locations: 1
Eligibility criteria

AF patients that regularly consume >5 alcoholic drink (*12 g of pure alcohol/dri... [+3]

Binge drinkers (alcohol dependence) [+10]

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Status: Not yet recruiting

Safety and Efficacy of Pulmonary Vein Isolation Using Pulsed-field Ablation (PFA) Combined with Either PFA-based Left Atrial Posterior Wall Isolation or Vein of Marshall Ethanol Ablation in Patients with Persistent Atrial Fibrillation

This study is designed to directly compare the safety and efficacy of PFA-based PVI+PWI vs PFA-based PVI+ VoM alcohol ablation in patients with Persistent AF.

Participants needed: 162
Trial details
Age: 18-85Biological sex: AllType: ObservationalSponsor: Texas Cardiac Arrhythmia Research FoundationUpdated: Mar 17, 2025
Eligibility criteria

Symptomatic persistent AF; 1st or redo ablation with PVI-only in the earlier pro... [+2]

• Previous PWI or VoM ablation procedure [+8]

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