Health Trials

Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors

The purpose of this first-in-human study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of TLN-499 in combination with venetoclax in participants with relapsed/refractory solid tumors.

Participants needed: 120
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Treeline Biosciences, Inc.Updated: Jul 28, 2026Locations: 3
Eligibility criteria

Adults ≥18 years of age [+6]

Active brain metastases [+4]

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Status: Recruiting

TLN-372 in Advanced KRAS Mutant Solid Tumors

The primary purpose of this study is to evaluate the safety, pharmacokinetics, and anti-tumor activity of TLN-372 as a single agent and in combination with other anti-tumor agents, in patients with advanced KRAS mutant solid tumors

Participants needed: 270
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Treeline Biosciences, Inc.Updated: Jul 28, 2026Locations: 11
Eligibility criteria

Patients must have measurable disease at study entry. [+3]

Patients must not have active brain metastases. [+6]

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Status: Recruiting

TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies in patients with relapsed or refractory Non-Hodgkin Lymphomas

Participants needed: 180
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Treeline Biosciences, Inc.Updated: Jul 20, 2026Locations: 14
Eligibility criteria

Participant must have measurable disease at study entry [+7]

Participants must not have current central nervous system (CNS) involvement. Par... [+6]

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