Clinical trials

Obsessive-Compulsive Disorder (OCD) is a common long-lasting, and disabling condition, affecting 1 in every 25 people in Portugal. People with OCD experience unwanted, repeated thoughts (obsessions) and repetitive behaviors (compulsions) that impair their daily lives and well-being. Even though OCD is common, many people do not get the specialized help they need. On average, it takes about 10 years from when symptoms first appear until someone receives proper treatment. This happens mainly because specialized care is mostly available in central hospitals, which makes it harder for people living outside big cities to get help. This delay is caused by a mix of factors: distance from specialized centers, financial barriers, and the stigma that still surrounds mental illness. These are well-known problems, and they highlight the urgent need for treatment options that are easier to access and can reach more people. The "Being with OCD" study aims to test whether an online program - combining cognitive-behavioral therapy (a well-established talk therapy approach) with mindfulness techniques - can effectively help people with OCD. Digital tools like websites and phone apps have become a promising way to make mental health care more available, more affordable, and easier to reach for more patients. Recent research shows that online cognitive-behavioral therapy programs for OCD can meaningfully reduce symptoms, working about as well as in-person therapy - especially when patients get some support from a clinician along the way. That said, these digital tools have not been tested enough in real-world, everyday settings, and few have been developed by actually listening to what patients and healthcare professionals need. This is a problem because it leads to low engagement by patients in these programs. In fact, a common pattern has been observed: people tend to start using digital therapy programs enthusiastically, but usage drops off quickly after the first few weeks - largely because these programs are not designed around what users actually want and need. At the same time, mindfulness - the practice of paying attention to the present moment without judgment - has become an increasingly valuable tool to cognitive-behavioral therapy for OCD. This combined approach can help reduce excessive worrying/overthinking, increase acceptance of difficult thoughts, and improve emotional control, helping people relate to their intrusive thoughts in a calmer, less reactive way. Among the different types of therapy available, mindfulness-based approaches tend to work particularly well in digital formats, with people sticking with them more and reporting higher satisfaction. For this reason, beyond testing whether our program works, this study will also look at how practical and well-received the program is for users. We will recruit 128 patients with OCD, split into two groups: a control group, who will continue receiving their usual care, and an intervention group, who will receive the online program in addition to their usual care. The program will be delivered through a website/app (usable on a computer or smartphone) and will run for 9 weeks, offering audio recordings, educational materials, and practical exercises based on cognitive-behavioral therapy and mindfulness. The goal is to help patients change unhelpful thought patterns and behaviors linked to their condition. Throughout the 9 weeks, participants will complete some tests and interviews so the research team can track changes in symptom severity, well-being, day-to-day functioning, and how practical and acceptable the program is to use. If this online program proves effective and usable, it could help expand access to OCD treatment for people who currently struggle to find care. Testing whether this kind of program is practical, well-received, and effective is an important step toward developing new mental health care options that are both clinically effective and genuinely accessible.

Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability. In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.

For patients living with Chronic Kidney Disease who are preparing to start hemodialysis, having a well-functioning arteriovenous fistula (AVF) is essential. Although the AVF is considered the best type of vascular access, its maturation process does not always go as expected-studies show that in 28% to 53% of cases, the fistula does not mature properly, making effective dialysis more difficult. There is growing interest in using physical exercise as a way to support AVF maturation. International guidelines even recommend arm exercises for this purpose. However, there is still no clear agreement on what type of exercise, how often, or how intense it should be. This study aims to evaluate whether a structured exercise program focused on the AVF arm can help improve the fistula's development and overall function.

The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells). Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.

Heart failure, characterized by high mortality and morbidity rates, frequent hospital admissions, and prolonged stays in cardiology wards, significantly impacts patients' quality of life. The REMOTI-HF is a single-center randomized controlled trial designed to assess the impact of remote monitoring, utilizing the HeartLogic and TriageHF algorithms, in patients with heart failure with implantable cardioverter defibrillator or cardiac resynchronization therapy. The primary endpoints include mortality, hospital admissions related to heart failure, and visits for worsening heart failure. Moreover, we will explore the full capabilities of these algorithms, by analysing the association of physical activity, measured by the devices, with the same key outcomes. Additionally, the research will explore the relationship between the absolute values provided by the algorithms and NT-proBNP values.