Health TrialsbyHealthPanel

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT)

The primary objective of this trial is to assess the efficacy of engasertib 40 mg once daily (QD) in reducing the frequency of epistaxis compared to placebo QD during 28 weeks of double-blind treatment in participants with moderate to severe HHT.

Participants needed: 240
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Vaderis Therapeutics AGUpdated: Sep 17, 2026Locations: 4
Eligibility criteria

Participants are ≥18 years of age at the Screening Visit. [+5]

History or current diagnosis of clinically significant electrocardiogram (ECG) a... [+4]

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Status: Not yet recruiting

Effect of a Known P-glycoprotein (P-gp) Inhibitor, Itraconazole, on the Pharmacokinetics (PK) of Engasertib

The primary objective of this trial is to assess the effect of a known P-gp inhibitor, itraconazole, on the PK of engasertib in healthy adult participants.

Participants needed: 27
Trial details
Phase: Phase 1Age: 18-55Biological sex: AllType: InterventionalSponsor: Vaderis Therapeutics AGUpdated: Sep 2, 2026
Eligibility criteria

Age of 18 to 55 years (both inclusive), at the time of signing the informed cons... [+7]

Any history or evidence of any clinically relevant cardiovascular, hepatic, rena... [+25]

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