Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.
The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).
Body mass index (BMI) of greater than or equal to (≥) 18.0 to less than or equal... [+1]
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
APOL1 genotype of G1/G1, G2/G2, or G1/G2 [+1]
Solid organ or bone marrow transplant [+5]
The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).
Age 18-80 years [+2]
History of thymic surgery within 6 months of screening [+2]
The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
Not listed
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine in participants with pain associated with diabetic peripheral neuropathy (DPN).
Body weight greater than or equal to (≥)45 kilogram (kg) [+3]
More than 3 missing daily NPRS scores during the 7-day Baseline Period [+2]
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single dose of VX-581 and multiple ascending doses of VX-581 alone and in combination with tezacaftor (TEZ)/deutivacaftor (D-IVA) or D-IVA for up to ten days.
Body mass index (BMI) of 18.0 to 32.0 kilogram per meter square (kg/m²) [+2]
History of febrile illness or other acute illness that has not fully resolved wi... [+1]
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
Clinical history of T1D with > 5 years of duration of insulin dependence [+3]
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Body weight greater than or equal to (≥) 45 kilogram (kg) [+3]
More than 3 missing daily NPRS scores during the 7-day Baseline Period [+1]
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VX-433 following single and multiple ascending doses, as well as to assess the effect of VX-433 on the PK of midazolam, bupropion, and hydroxybupropion.
Body mass index (BMI) of 18.0 to 30.0 kilogram per meter square (kg/m2), inclusi... [+2]
History of febrile illness or other acute illness that has not fully resolved wi... [+2]
The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)
Diagnosis of diabetes mellitus type 1 or type 2 with [+2]
Painful neuropathy other than DPN [+2]
The purpose of the study is to evaluate the pharmacokinetics (PK) of suzetrigine (SUZ) and its active metabolite in breast milk of lactating female participants. In addition, the purpose is also to evaluate the relative infant dose (RID), safety and tolerability of SUZ and its active metabolite in lactating female participants.
Body mass index of greater than or equal to (≥) 18.0 to less than (<) 40.0 kilog... [+4]
History of febrile illness or other acute illness that has not fully resolved wi... [+3]
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of VX-272.
Body mass index (BMI) of 18.0 to 32.0 kilogram per meter square (kg/m²) [+2]
History of febrile illness or other acute illness that has not fully resolved wi... [+1]
This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.
Clinical history of T1D with greater than or equal to (≥)5 years of insulin depe... [+2]
Prior islet cell transplant, organ transplant (other than kidney transplant), or... [+1]
This is a single-dose, open-label study in participants with transfusion-dependent β-thalassemia (TDT) or severe sickle cell disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) using CTX001.
Eligible for autologous stem cell transplant as per investigator's judgment. [+4]
A willing and healthy 10/10 human leukocyte antigen (HLA)-matched related donor... [+5]