Health Trials

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Condition / disease
Location
Status: Not yet recruiting

A Long-Term Follow-Up Trial for Participants Enrolled in CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) Trials

This is an open label, multi-center, long-term safety and efficacy follow-up trial for participants who have been treated with Senza5 CART5.

Participants needed: 30
Trial details
Age: 18-100Biological sex: AllType: ObservationalSponsor: Vittoria BiotherapeuticsUpdated: Jul 30, 2026
Eligibility criteria

Provision of written informed consent by the participant or provision of written... [+2]

There are no exclusion criteria.

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Status: Recruiting

CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) for T Cell Non-Hodgkin Lymphoma (NHL)

This is an open-label phase I study to determine the safety and recommended phase 2 dose (RP2D) of Senza5 CART5 cells in patients with relapsed or refractory CD5 positive nodal T cell NHL. RP2D will be based on the safety, tolerability, pharmacokinetics, and preliminary efficacy of Senza5 CART5 cells. This trial will evaluate up to 5 dose levels using the Bayesian Optimal Interval (BOIN) design enrolling 3 patients in each cohort to assess safety and achieve therapeutic levels so that the RP2D of Senza5 CART5 cells given as a single IV infusion can be determined.

Participants needed: 30
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Vittoria BiotherapeuticsUpdated: Nov 10, 2025Locations: 2
Eligibility criteria

Histologically or cytologically confirmed relapsed or refractory (r/r) CD5-posit... [+4]

Pregnant or lactating (nursing) women. [+16]

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