Clinical trials

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Condition / disease
Location
Status: Recruiting

Evaluation of YB-101 for Safety, Tolerability, Pharmacokinetics, and Efficacy in Graves' Disease

This study is being conducted to look at the effect YB-101 has on thyroid function. This study will also evaluate how safe and well tolerated YB-101 is and how it is distributed through the body. The study consists of a part 1, blinded treatment period, and a part 2 double-blinded treatment period. Participants will receive YB-101 or Placebo subcutaneously. Participants who participate in Part 1 can not participate in Part 2. Participants will complete 34-39 in-clinic visits in Part 1 or Part 2 over an approximate 40 week period.

Participants needed: 232
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Yarrow Bioscience, Inc.Updated: Jul 28, 2026Locations: 28
Eligibility criteria

Have a documented diagnosis of Graves' Disease confirmed by the presence of thyr... [+2]

Previously treated with radioactive iodine (RAI) therapy or underwent total thyr... [+5]