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Condition / disease
Location
Status: Not yet recruiting

Model-Informed Precision Dosing on Cyclosporine Therapy in Hematopoietic Stem Cell Transplant Recipients

The purpose of this study is to develop a new tool that helps doctors choose the right cyclosporine dose for patients undergoing bone marrow transplantation. The tool is designed to predict the best dose using sparse sampling, making it practical for everyday clinical care. It combines information about population pharmacokinetics of cyclosporine with advanced artificial intelligence techniques, including machine learning and deep learning. This tool aims to improve treatment, personalize dosing for each patient, and reduce the risk of graft-versus-host disease.

Participants needed: 300
Trial details
Age: 2-65Biological sex: AllType: ObservationalSponsor: Yasmin medhat munir MohamedUpdated: Jul 10, 2026
Eligibility criteria

• CsA therapy indicated alone or in combination for GVHD prophylaxis. [+2]

• Inaccurate sampling or dose administration times. [+2]