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Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

SHR-1701 in Combination With Irinotecan Liposome (II) for Second-line Treatment of ESCC After Immunotherapy

This study is a single-arm, exploratory clinical trial aimed at evaluating the efficacy and safety of SHR-1701 in combination with liposomal irinotecan (II) in patients with esophageal squamous cell carcinoma who have received prior immunotherapy. Eligible patients with esophageal cancer will be treated with SHR-1701 in combination with liposomal irinotecan (II).

Participants needed: 33
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Zhigang LiUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Signed written informed consent, voluntarily participating in this study; [+12]

1. Active or untreated central nervous system (CNS) metastases (e.g., brain or l... [+3]

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Status: Not yet recruiting

Active Surveillance After Neoadjuvant Adebrelimab Combined With Chemoradiotherapy for Resectable ESCC

In this prospective trial, patients demonstrating clinical complete response (cCR) as determined by a standard response assessment protocol (incorporating clinical and molecular diagnostic methods) will be offered organ-sparing management following neoadjuvant therapy with adebrelimab (anti-PD-L1) concurrent with chemoradiotherapy. The primary endpoint is 2-year overall survival rate in this watch-and-wait cohort.

Participants needed: 164
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Zhigang LiUpdated: May 15, 2025Locations: 1
Eligibility criteria

Subjects signed the informed consent and volunteered to participate in the study... [+10]

anti-tumor interventions such as radiotherapy, chemotherapy, or other medication... [+15]

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