3T Magnetic Resonance Neurography
ConditionHealthy Adults
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBalgrist University Hospital
About this trial
The goal of this observational study is to evaluate whether optimized high-resolution MRI can better visualize very fine nerves in the cervical spine and neck region compared to standard MRI. The main question it aims to answer is:
Can high-resolution MRI reliably show small nerves and potentially detect their injuries or diseases that are often invisible on conventional MRI scans?
Participants will come once to Balgrist University Hospital for a one-hour visit. They will fill out a questionnaire and have a single 30-minute MRI scan of the cervical spine without contrast.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
<18 years of age
pregnancy
known cervical spine pathology or history of neck surgery
contraindication to perform non-contrast-enhanced MRI
Trial population
Healthy volunteers
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
High-resolution three-dimensional magnetic resonance neurography protocols
Diagnostic testClinical standard three-dimensional magnetic resonance neurography sequences with high spatial resolution
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Healthy volunteers1 intervention
Trial outcomes
Primary outcomes
1
Proportion of visible small-caliber nerve segments
Visibility of small-caliber cervical nerves (phrenic, spinal accessory, dorsal scapular, vagus nerve) per segment (proximal, midsegment, distal) on both sides (left/right) per volunteer. Two board-certified radiologists with experience in MR Neurography will independently determine visibility (binary score: 0 = not visible, 1 = visible). Visibility is defined as continuous depiction of the nerve segment over its entire length with signal intensity clearly distinguishable from background tissue.
Time frame
Within 12 weeks after MRI acquisition during radiological readoutSecondary outcomes
1
Image quality score across different acceleration factors
Image quality of small-caliber cervical nerves across varying acceleration factors will be independently assessed by two radiologists using a 4-point Likert scale (0 = poor/non-diagnostic, 2 = moderate, 3 = good, 4 = excellent).
Time frame
Within 12 weeks after MRI acquisition during radiological readout2
Inter-reader agreement for visibility and image quality
Reliability of visibility and image quality of small-caliber cervical nerves and nerve segments will be assessed by inter-reader agreement.
Time frame
Within 12 weeks after MRI acquisition during radiological readout3
Frequency of anatomic variants
Frequency of anatomical variants of small-caliber cervical nerves, reported as percentage of volunteers.
Time frame
Within 12 weeks after MRI acquisition during radiological readoutSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: