Health TrialsbyHealthPanel

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

ConditionsSpontaneous Coronary Artery DissectionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorMayo Clinic

About this trial

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography

For controls: no cardiac disease history

Disqualifiers

Pregnancy

Known or suspected unstable cardiac condition within 4 weeks of the study

Active treatment with anticoagulation or dual antiplatelet therapy

Prisoner

Trial design

Design model

Parallel

Treatments tested in this trial

  • Arterial Tonometry

    Other intervention

    We will measure arterial stiffness using arterial tonometry.

  • Echocardiogram

    Diagnostic test

    We will collect limited ultrasound images of the heart.

  • Carotid Ultrasounds

    Diagnostic test

    We will perform ultrasound imaging of the carotid artery.

  • Elastography

    Diagnostic test

    We will measure the elastic properties of the arteries using elastography.

  • Ankle-Brachial Index

    Other intervention

    We will measure the ankle-brachial index to assess peripheral artery blood flow.

  • Microneurography with sympathoexcitatory maneuvers

    Other intervention

    We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Spontaneous coronary artery dissection (SCAD) groupOther 6 interventions
Group B: Healthy Control GroupOther 6 interventions

Trial outcomes

Primary outcomes

1

Arterial thickness

Measured by carotid ultrasound intimal media thickness reporting in mm

Time frame
Baseline
2

Arterial stiffness

Measured by carotid ultrasound pulse wave velocity reporting in m/s

Time frame
Baseline
3

Baroreflex sensitivity

The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)

Time frame
Baseline
4

Sympathetic response to stress

Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).

Time frame
Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Source ClinicalTrials.gov
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