Acute Ocular Effects of Cigarette Smoking
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorIstanbul University
About this trial
This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared. The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy adults aged 18 to 60 years
Current smokers in the smoking group
Never-smokers in the control group
Willing and able to undergo ophthalmic examination and Pentacam AXL measurements
Disqualifiers
History of ocular surgery or ocular trauma
Presence of corneal disease, retinal disease, or ocular surface disorder
Clinically significant dry eye disease
Contact lens use within the last 2 weeks
Trial population
Healthy adult smokers and non-smokers aged 18 to 60 years are planned to be included in this single-center study.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Cigarette Smoking Exposure
Other interventionParticipants in the smoking group smoked cigarettes during a standardized 10-minute outdoor period between baseline and post-exposure assessments.
No Smoking Exposure
Other interventionParticipants in the control group remained in the same outdoor environment for 10 minutes without smoking between baseline and post-exposure assessments.
Treatment groups
90 Participants
are divided into 2 treatment groupsGroup A: Smokers1 intervention
Group B: Non-smokers1 intervention
Trial outcomes
Primary outcomes
1
Change in Pentacam-measured corneal pachymetry at the pupil center after acute cigarette smoking exposure
Change (post-exposure minus baseline) in corneal pachymetry at the pupil center, measured in micrometers (µm) using Pentacam. The magnitude of change will be compared between smokers and non-smokers.
Time frame
Baseline and immediately after a standardized 10-minute outdoor exposure periodSecondary outcomes
1
Change in Pentacam-measured corneal densitometry in the anterior 0-2 mm zone after acute cigarette smoking exposure
Change (post-exposure minus baseline) in corneal densitometry in the anterior 0-2 mm zone, measured in grayscale units (GSU) using Pentacam. The magnitude of change will be compared between smokers and non-smokers.
Time frame
Baseline and immediately after a standardized 10-minute outdoor exposure periodSponsors and contacts
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Source ClinicalTrials.gov