Adversity, Brain and Opioid Use Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorUniversity of Michigan

About this trial

The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.

Eligibility criteria

Qualifiers

Fluent in English

Able to give informed consent

Normal/corrected-to-normal vision and hearing

Diagnosis of OUD

Disqualifiers

Pregnancy

Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)

Actively suicidal

Contraindication for MRI

Trial design

Treatments tested in this trial

  • Magnetic Resonance Imaging (MRI)
  • Computer Tasks

Treatment groups

185 Participants
are divided into 3 treatment groups

Sponsors and collaborators

University of Michigan

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator