This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.
Mechanically ventilated adult patients ≥ 21 years.
Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.
Hemodynamically stable [mean arterial pressure (MAP) ≥60 mmHg].
All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.
Patients with neuromuscular disorders affecting respiratory drive
Glasgow Coma Scale (GCS) score below 8
Cervical spinal cord injury
Receipt of neuromuscular blockers within the previous 24 hours