Analgesic Efficacy of Multiple Mid-Transverse Process to Pleura (MTP) Block and PCA in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorTanta University

About this trial

This study aims to compare the analgesic efficacy of multiple mid-transverse process to pleura (MTP) block and PCA in idiopathic scoliosis patients undergoing posterior spinal fusion surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years.

Both sexes.

American Society of Anesthesiology (ASA) physical status I-II.

Idiopathic scoliosis patients undergoing posterior spinal fusion surgery.

Disqualifiers

Patients with pre-existing infection at block site.

Known allergy to study drugs.

Coagulation disorder.

History of psychiatric illness.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Multiple Mid-Transverse Process to Pleura (MTP) Block

    Other intervention

    Patients will receive multiple mid-transverse process to pleura (MTP) block after induction of anesthesia.

  • Morphine

    Drug

    Patients will receive IV-PCA. Morphine is generally administered as an initial loading dose of 0.05-0.1 mg/kg before the end of surgery, with PCA settings of a bolus dose of 0.01-0.03 mg/kg, a lockout interval of 6-10 min, and a background infusion of 0.01-0.02 mg/kg/h.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: MTP groupExperimental treatment 1 intervention
Group B: PCA groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Degree of pain

The degree of pain will be assessed using the Visual Analogue Scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.

Time frame
24 hours postoperatively

Secondary outcomes

1

Intraoperative fentanyl consumption

Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).

Time frame
Intraoperatively
2

Time to the first request for the rescue analgesia

Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated).

Time frame
24 hours postoperatively
3

Total morphine consumption

Postoperative analgesia was provided by morphine (3 mg IV in Multiple Mid-Transverse Process to Pleura (MTP) Block group or 0.01 mg/kg bolus with a 15-min lockout in PCA group) to keep the Visual Analogue Scale (VAS) at rest less than 4.

Time frame
24 hours postoperatively
4

Mean arterial pressure

Mean arterial pressure will be recorded preoperatively, before the block is performed, and every 15 minutes until the end of the surgery.

Time frame
Every 15 minutes until the end of the surgery (Up to 2 hours)

Other outcomes

Sponsors and contacts

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