Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age25+
SponsorRegion Skane
About this trial
The study project aims at examining molecular markers in synovial fluid, bone and articular cartilage from osteoarthritic thumb basal joints. The degradation of extracellular matrix (ECM) proteins in thumb basal joints will be evaluated in association to the metabolic profile of the patient, but we also aim to compare the ECM degradation and inflammatory profiles with articular cartilage degradation ECM profile from knee joints with osteoarthritis. A third aim is to evaluate associations between patient-reported hand function, pain, strength and range of thumb motion to analyses of synovial fluid.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Men and women age ≥ 25 years
Radiologically confirmed and symptomatic thumb basal joint osteoarthritis (OA) planned for trapeziectomy
Disqualifiers
Previous surgery to the affected thumb basal joint
Post-traumatic thumb basal joint OA
Rheumatoid arthritis or other chronic inflammatory arthritis, history of psoriasis affecting joints, gout or pseudogout
Ongoing infection in the hand or wrist
Trial population
All patients fulfilling the eligibility criteria and are scheduled for surgery at any of two study centres; Department of hand surgery, Skane university hospital or Aleris Malmö Arena (private clinic), due to symptomatic thumb basal joint OA are invited to participate. Indications for surgery at these to clinics are; 1) persistent pain and pain at rest, 2) have tried conservative treatment with inadequate effect.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Trapeziectomy
Procedure/SurgeryPatients scheduled for trapeziectomy due to thumb basal joint osteoarthritis are invited to participate. Synovial fluid is aspirated before the joint is opened. Bone and cartilage are collected. Blood samples are obtained preop. Patients are measured with grip strength, pinch strength, range of thumb motion, body mass index, central obesity and blood pressure.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Serum cholesterol levels
Blood samples are drawn from the patients and analysed according to Swedish laboratory standards
Time frame
Serum cholesterol levels are drawn at baseline (i.e. the day of surgery)Sponsors and contacts
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Source ClinicalTrials.gov