Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorRuijin Hospital
About this trial
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp electroencephalogram (EEG) of the frontal cortex were recorded from patients undergoing deep brain stimulation (DBS) surgery during the recovery from general anesthesia, in order to explore the changes and relevance of deep brain nuclei firing and cortex activity during the recovery of consciousness from general anesthesia .
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
18-75 years old
ASA (American Society of Anesthesiologists) classification I-III
Those who meet the indications for DBS surgery
Right-handed with normal listening and speaking abilities
Disqualifiers
Patients with cognitive impairment [Montreal Cognitive Assessment (MoCA) score less than 26 points];
Patients with severe depression [Beck Depression Inventory (BDI-II) score greater than or equal to 25 points];
Patients with important organs dysfunction, such as heart, lungs, liver, and kidneys; or patients with unstable vital signs;
Patients who are expected to enter the ICU after surgery;
Trial population
Patients who meet the surgical indications and voluntarily undergo DBS surgery at the Functional Neurosurgery Department of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from April 2024 until October 2026.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
No interventions
Other interventionNo interventions were given to patients except for the deep brain stimulation surgery they originally planned to take
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Number of Participants With Changes in the Local Field Potential from the Deep Brain Nuclei and the Scalp Electroencephalogram of the Frontal Cortex.
Number of participants with changes in the local field potential from the deep brain nuclei and the scalp electroencephalogram of the frontal cortex during recovery of consciousness from general anesthesia. The recovery of consciousness is defined as the patient can follow the experimenter's verbal command to open mouth and extubate the endotracheal tube.
Time frame
2 hours.Sponsors and contacts
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Source ClinicalTrials.gov