Peripheral venous catheters (PVCs) are the most commonly used intravascular medical devices in healthcare establishments. Although essential in patient care, PVCs represent a significant risk factor for nosocomial infections, as shown by the results of the national prevalence survey. While the main pathophysiological mechanisms are known, the specific factors driving the transition from simple colonization to infection remain unclear. This project aims to identify the major factors involved in the occurrence of bacterial infections related to the colonization of peripheral venous catheters.
Patient hospitalized in a care unit of the NOVO hospital (Pontoise site)
Major patient for whom a peripheral venous catheter has been in place for at least 2 days and at most 7 days, with or without signs of inflammation
Antibiotic treatment by any route
Patient with viral hepatitis, or human immunodeficiency virus (HIV) or suspected epidemic and biological risk (EBR)
Patient unable to understand and give non-opposition to study participation
Patient under guardianship
Patient hospitalized in a care unit of the NOVO hospital
Case-control
Prospective
Inflammatory catheters: catheter removed because of infection at insertion site
Diagnostic testVerification of inclusion and non-inclusion criteria (at least 2 days and at most 7 days, with or without signs of inflammation). The doctor or a qualified nurse orally informs the patient when catheter removal is planned. The information and non-opposition note are given to the patient, and the information procedure is recorded in the medical record. The catheter is removed and collected under aseptic conditions by the nurses in the various departments, in a dry sterile tube. The tube is then labelled and stored at a maximum of 4°C. The catheter is sent to the hospital's biology laboratory before being collected by the approved carrier for delivery to the ERRMECe laboratory from CYU. All tests are performed in the ERRMECe laboratory. Collected catheters are subsequently analysed to assess the bacterial diversity of biofilms using molecular biology techniques and Next-Generation Sequencing (NGS), in parallel with biofilm structural analysis microscopy using a Scanning Electron Microsc
Non-inflammatory catheters: catheter removed because it is no longer relevant to keep it in place
DeviceVerification of inclusion and non-inclusion criteria (at least 2 days and at most 7 days, with or without signs of inflammation). The doctor or a qualified nurse orally informs the patient when catheter removal is planned. The information and non-opposition note are given to the patient, and the information procedure is recorded in the medical record. The catheter is removed and collected under aseptic conditions by the nurses in the various departments, in a dry sterile tube. The tube is then labelled and stored at a maximum of 4°C. The catheter is sent to the hospital's biology laboratory before being collected by the approved carrier for delivery to the ERRMECe laboratory from CYU. All tests are performed in the ERRMECe laboratory. Collected catheters are subsequently analysed to assess the bacterial diversity of biofilms using molecular biology techniques and Next-Generation Sequencing (NGS), in parallel with biofilm structural analysis microscopy using a Scanning Electron Microsc
Bacterial diversity of biofilms in PVCs according to inflammatory symptoms
Relative abundance of bacteria within biofilms present in CVPs as identified by NGS, according to inflammatory symptoms.
Biofilms structural morphology in PVCs
Qualitative imaging of microbial biofilms in PVCs using Scanning Electron Microscopy
Bacterial diversity of biofilms in PVCs according to type of substances administered through the vascular route
Relative abundance of bacteria within biofilms present in PVCs as identified by NGS, according to the type of substances received by patients through the vascular route
Bacterial diversity of biofilms in PVCs according to catheter dwell time
Relative abundance of bacteria within biofilms present in CVPs as identified by NGS, according to catheter dwell time.
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Hôpital NOVO
Lead sponsor
Université de Cergy Pontoise
Collaborator
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