Animal and Plant Proteins and Glucose Metabolism

ConditionsMetabolic Syndrome Metabolic Syndrome, Protection Against Glucose Metabolism Disorders

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age21-70

SponsorUniversity of Missouri-Columbia

About this trial

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

age: ≥21 and ≤70 years;

BMI: >24.5 and <32.5 kg/m2;

habitual protein intake <0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and

weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.

Disqualifiers

prediabetes or type 2 diabetes;

evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate <60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);

vegetarians or vegans;

intolerance or allergies to ingredients in the metabolic meal or intervention diet;

Trial design

Design model

Parallel

Treatments tested in this trial

High animal protein isolate
Other intervention
Increased dietary protein content from animal protein isolates
High animal protein whole food
Other intervention
Increased dietary protein content from animal protein whole food
High plant protein isolate
Other intervention
Increased dietary protein content from plant protein isolates
High plant protein whole food
Other intervention
Increased dietary protein content from animal protein whole food

Treatment groups

100 Participants

are divided into 5 treatment groups

Group A: Standard protein (control)No intervention 0 interventions

Group B: High animal protein isolateExperimental treatment 1 intervention

Group C: High animal protein whole foodExperimental treatment 1 intervention

Group D: High plant protein isolateExperimental treatment 1 intervention

Group E: High plant protein whole foodExperimental treatment 1 intervention