Ankylosing Spondylitis
ConditionAnkylosing Spondylitis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16-80
SponsorSohag University
About this trial
The goal of this observational study is to measure the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group.
The main question it aims to answer is:
Does the disease activity, severity, serum level of cytokines (IL-17, IL-38, and IL-41) are affected by the HLA-b27 gene positivity?
Researchers will compare the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group to see if there significant differences in serum levels of interleukins 17, 38, 41 in AS patients and healthy control group.
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Eligibility criteria
This trial accepts healthy volunteersQualifiers
patients who are diagnosed clinically as ankylosing spondylitis (both active or stable), of either sex , who met the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis.
Disqualifiers
Patients with any autoimmune disorder, chronic illnesses as diabetes mellitus, acute and chronic infectious diseases, malignancy.
Trial population
Participants will be recruited from the outpatient clinics of Rheumatology and Rehabilitation Department, Sohag University Hospitals.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
84 Participants
are grouped into 2 trial groupsGroup A: Cases
Group B: Healthy Controls
Trial outcomes
Primary outcomes
1
collection of blood samples from paticipants
Time frame
from March 2026 to August 20262
measurement of serum level of Interleukin 17 in participants
Time frame
From September 2026 to October 20263
Measurement of serum level of Interleukin 38 in participants
Time frame
from September 2026 to October 20264
measurement of serum level of Interleukin 41 in participants
Time frame
from September 2026 to October 2026Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: