About this trial
The success rate of single-procedure atrial arrhythmia-free survival particularly ranged from 40% to 66% in persistent AF ablation. However, The surgical Cox maze III procedure has been established to be an effective curative strategy for AF with an AF-free survival rate of more than 95%. The main reason is the difficulty of creating continuous, transmural, and durable lesions by catheter ablation, especially when the procedure is performed on some complex anatomical structures in which epicardial muscular bundles may serve as components of the reentrant circuits.
The durability of the conduction block is a crucial factor for long-term effective AF ablation since previous studies reported that the reconnected Pulmonary veins contributed to the atrial tachycardia recurrence after persistent AF ablation. In addition, it is possible that the inadequate lesions accidentally produce new arrhythmogenic substrates. Therefore, new and better techniques are always chosen to minimize the reconnection of Pulmonary vein isolation (PVI) and additional ablation.
For paroxysmal AF, the ablation strategy of PVI plus superior vena cava isolation is chosen while PVI, superior vena cava isolation, and linear ablation of linear ablations of the mitral isthmus, roofline and posterior wall line of the left atrium, and cavotricuspid isthmus (CTI) for persistent AF. Any symptomatic or asymptomatic atrial arrhythmia lasting more than 30 seconds was regarded as an AF recurrence after a 3-month blanking period. The primary outcome was defined as 12-month atrial arrhythmia-free survival. The secondary outcomes include the block rate of PVI, superior vena cava isolation, and all linear ablations.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Radiofrequency catheter ablation for the first time
AF rhythm recorded by ECG
Disqualifiers
Thrombosis in left atrium
Left ventricular ejection fraction of < 35%
Abnormal thyroid function
Previous history of AF radiofrequency ablation and CABG
Trial population
There are ECG which can be definitely diagnosed as atrial fibrillation, that is: P wave disappeared, replaced by F wave, frequency 350-600 times / min, QRS wave rhythm is absolutely irregular, RR interval is uneven, QRS wave shape is normal
Trial design
Cohort
Prospective
Treatments tested in this trial
Pulmonary vein isolation plus superior vena cava isolation
Procedure/SurgeryPulmonary vein isolation plus superior vena cava isolation
PVI, superior vena cava isolation, and linear ablation of linear ablations of the mitral isthmus, roofline and posterior wall line of the left atrium, and cavotricuspid isthmus
Procedure/SurgeryPVI, superior vena cava isolation, and linear ablation of linear ablations of the mitral isthmus, roofline and posterior wall line of the left atrium, and cavotricuspid isthmus
Treatment groups
Trial outcomes
Primary outcomes
AF recurrence
Any symptomatic or asymptomatic atrial arrhythmia lasting more than 30 seconds after a 3-month blanking period
Secondary outcomes
initial block rate
initial block rate of pulmonary veins isolation, superior vena cava isolation and additional ablation lines
Sponsors and contacts
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