About this trial
To evaluate optimal workout environments, a 12-week study assigned women with moderate-to-severe lipedema to three distinct protocols: supervised pool workouts, equivalent land-based training, or basic standard monitoring. Researchers tracked walking endurance alongside tissue composition, fluid levels, pain intensity, and general well-being. The trial posited that structured activity beats routine care alone, with water-based exercise potentially offering superior relief due to buoyancy and hydrostatic fluid compression.
Eligibility criteria
Qualifiers
Women diagnosed with lipedema for at least five years
Had stage 2 or 3 and type 2 or 3 disease
Had a body mass index of ≥25 and <40 kg/m²
Able to walk independently, with or without their usual assistive device
Disqualifiers
Had clinically significant lymphedema, uncontrolled chronic venous insufficiency, acute thrombosis, or another major cause of lower-limb edema
Had open wounds, active skin infection, fever, or another infectious condition incompatible with pool use
Had uncontrolled cardiovascular, metabolic, respiratory, or neurological disorder that could compromise exercise safety; a cardiac pacemaker or congestive heart failure; pregnancy; active cancer or ongoing chemotherapy, immunotherapy, or radiotherapy
Had history of bariatric surgery, recent major surgery, or liposuction; current use of weight-loss medication
Trial design
Treatments tested in this trial
- aquatic therapy
- land- based exercise
- usual care