Clinical trials

evaluation of color difference between zirconia reinforced lithium silicate (celtra press) VS lithium disilicate (Emax) in relation to natural tooth structure to determine which monolithic material will provide restoration with exact shade and optical properties as natural tooth structure.

Pulmonary dysfunction can be developed as a result of complications caused by direct thermal injury to the respiratory tract, smoke irritations, and respiratory tract infection. Although the survival rates of patients with burn injury have increased because of improved acute management, pulmonary complications have continued to be the main cause of mortality in patients with burns. The patients who survive suffer from persistent physiological impairments, limited aerobic capacity, increased skeletal muscle catabolism, and decreased muscle strength/endurance. Rehabilitation strategies for the long-term recovery in patients with burns aim to improve the physical function and independence in daily activities.

The goal of this clinical trial is to compare the effectiveness of different physical therapy delivery models in treating chronic non-specific neck pain in adults aged 20-40 years with a history of neck pain for three months or longer. The main questions it aims to answer are: * Which approach (tele-rehabilitation, face-to-face exercises, or a mixed model) is most effective at reducing neck pain intensity and functional disability? * Are there significant differences between the three models in improving cervical range of motion, kinesiophobia (fear of movement), patient satisfaction, and adherence to the exercise program? Researchers will compare three groups to see if the delivery model affects outcomes: 1. A tele-rehabilitation group receiving real-time, video-guided exercise sessions. 2. A face-to-face group receiving traditional, in-person supervised exercise sessions. 3. A mixed-model group receiving a combination of both tele-rehabilitation and face-to-face sessions. Participants will: * Be randomly assigned to one of the three groups. * Engage in a structured exercise program for 45-60 minutes per session, three times a week for six weeks. * Follow a phased exercise protocol that begins with mobility and pain reduction, progresses to strengthening, and finishes with endurance and functional training. * Complete assessments for pain, disability, range of motion, and other outcomes at the beginning and end of the 6-week intervention, with a final follow-up at 3 months.

The goal of this clinical trial is to learn if a digital health-supported cardiac rehabilitation program works to improve functional capacity, adherence, quality of life, and psychological status in cardiac patients. It will also learn about the effect of digital health support when added to conventional outpatient cardiac rehabilitation. The main questions it aims to answer are: Does a digital health-supported cardiac rehabilitation program improve functional capacity? How does digital health support affect patients' adherence to cardiac rehabilitation? How does the program affect patients' quality of life and psychological status? Researchers will compare digital health-supported cardiac rehabilitation combined with conventional outpatient cardiac rehabilitation to conventional outpatient cardiac rehabilitation alone to determine whether digital support improves functional, behavioral, and psychological outcomes in phase II cardiac patients. Participants will: Be randomly assigned to receive either digital health-supported hybrid cardiac rehabilitation in addition to conventional outpatient cardiac rehabilitation or conventional outpatient cardiac rehabilitation alone. Have their functional exercise capacity assessed using the Six-Minute Walk Test (6MWT) as the primary outcome measure. Complete assessments to evaluate cardiac rehabilitation adherence and engagement, health-related quality of life, and psychological status. Have resting heart rate and blood pressure monitored as part of the clinical assessment. Participants in the digital health-supported group will also use digital health tools for activity monitoring, exercise adherence, reminders, education, communication, and weekly telecoaching.

This study will investigate the effect of core-based movement and nutritional counselling on stress, serum cortisol, and lipid profile in overweight women with functional constipation. Sixty overweight women with functional constipation will be randomly assigned into two equal groups. The study group will include 30 participants who will receive a core-based movement exercise program for 8 weeks, two sessions per week, in addition to guideline-based nutritional counselling. The control group will include 30 participants who will receive guideline-based nutritional counselling only for 8 weeks. The outcomes will include perceived stress, serum cortisol level, lipid profile, stool form, sleep quality, and quality of life.

The goal of this observational study is to learn if taking extra iron pills after weight loss surgery helps prevent low iron and anemia compared to just taking a standard multivitamin. The main question it aims to answer is: Does a specific iron supplementation plan lower the number of patients who develop iron deficiency anemia in the 6 months after sleeve gastrectomy surgery? Researchers will compare two groups of patients from different hospital units to see if the extra iron works: Patients from one unit who take a prophylactic iron supplement (Ferrodep, 60 mg per day) in addition to their standard multivitamin. Patients from another unit who take only a standard multivitamin (Centrum Silver). Participants in this study will: * Have their blood tested for iron and anemia levels before surgery, and again at 3 and 6 months after surgery, as part of their regular post-operative care. * Be asked about their health and quality of life during follow-up clinic visits. * Have their medical information from their hospital records reviewed by the study team to track their progress.

The goal of this clinical trial is to learn if shell technique is useful for implant placement site preparation in adults. The main questions it aims to answer are: Does using xenograft in this technique can reduce the amount of bone harvested from intra oral sites and reduce postoperative complications while offering enough bone to support endosseous implants with long term success? Researchers will compare autogenous bone blocks to xenograft bone blocks in the shell technique ridge augmentation. Participants will undergo ridge augmentation surgery, then have implants placed in the augmented area, then receive implant supported restorations afterwards.

To evaluate the effectiveness of a structured oral health educational program on oral hygiene status and oral health-related quality of life (OHRQoL) among children diagnosed with β-thalassemia.

The primary goal of this RCT is to evaluate the effects of isokinetic training compared to plyometric training after 4weeks of intervention in patients aged 18-40 years who have undergone ACLR surgery. The primary question to answer is which of the two interventions (isokinetic or plyometrics) has superior effect in the improvement of muscular strength, functional performance and patient-reported outcomes in ACLR patients. Participants will be divided into two groups. both groups received standard rehabilitation for 4 weeks, followed by adding: Group 1: receives isokinetic training, Group 2: receives plyometric training.

The primary goal of this RCT is to evaluate the effect of adding plyometric training after 12 weeks of standard intervention in patients aged 18-40 years who have undergone ACLR surgery. The primary question to answer is does adding plyometrics training to the standard rehabilitation program has superior effect in the improvement of muscular strength, dynamic balance and functional performance in ACLR patients. Participants will be divided into two groups. Group 1 receives standard program for 18 weeks, and Group 2 receives the same standard program for 18 months, but adding the plyometrics training at week 12.

The aim of this randomized controlled clinical trial is to evaluate and compare the clinical performance of a Ni-Ti shape-memory sectional matrix system versus a conventional sectional matrix system in Class II direct composite restorations. The study will specifically assess the following clinical parameters: 1. Proximal contact tightness 2. Proximal contour quality 3. Fracture and retention of the restoration 4. Marginal adaptation These clinical parameters will be evaluated immediately after restoration placement and after a 1-year follow-up using standardized clinical assessment methods, including the FDI criteria, dental floss evaluation, and radiographic assessment, where applicable. Fracture and retention, and marginal adaptation will be assessed according to predefined scoring criteria.

Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy

This randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of immediate implant placement using xenograft combined with hyaluronic acid versus xenograft alone in the esthetic zone. Patients requiring extraction of a non-restorable tooth followed by immediate implant placement will be randomly allocated to two groups. In the intervention group, the jumping gap between the implant and facial bone wall will be grafted with xenograft combined with hyaluronic acid, while in the control group, xenograft alone will be used. The primary outcome is the radiographic change in the labio-palatal ridge width. Secondary outcomes include pink esthetic score, implant stability, crestal bone loss, and the amount of bone labial to the implant. Patients will be followed for up to 12 months postoperatively.

This study evaluates the clinical effectiveness of using a patient's own subepithelial connective tissue graft as a natural barrier membrane during simultaneous hard and soft tissue augmentation in areas of the jawbone with insufficient horizontal width. The procedure will be performed during delayed dental implant placement. The study aims to assess changes in hard and soft tissue dimensions and the clinical outcomes of this approach in patients with horizontally deficient alveolar ridges.

Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of functional disability in cancer survivors. Patients with CIPN typically present with numbness, tingling, burning pain, and loss of proprioception, particularly in distal extremities. The sensory and motor deficits associated with CIPN impair balance and increase the likelihood of falls, which may lead to injury, decreased independence, and reduced quality of life. Loss of proprioception and vibration sense in CIPN disrupts sensory integration required for maintaining postural control. Consequently, individuals with CIPN often demonstrate gait instability, impaired balance, and increased sway during standing and walking tasks. Recent evidence suggests that immersive VR rehabilitation is feasible and safe for individuals with moderate to severe CIPN. Additionally, VR-based interventions may improve sensory symptoms and postural stability without adverse effects. Studies have demonstrated that immersive VR training improves the integration of visual and proprioceptive information, leading to enhanced postural stability in individuals with balance impairments. Virtual reality technology has shown promising results in balance rehabilitation by providing interactive environments that enhance patient engagement and stimulate multisensory feedback mechanisms. So, the purpose of the current study is to investigate the effect of immersive virtual reality on postural control and risk of fall in patients with chemotherapy-induced peripheral neuropathy.

This pilot randomized controlled clinical trial will evaluate and compare Banded Helical and Gerber space regainers in children aged 7-9 years with unilateral space loss following premature loss of a primary second molar. The study will assess the effectiveness of the two appliances in regaining lost space and evaluate treatment duration, patient discomfort, gingival inflammation, plaque accumulation, and appliance failure.

The goal of this randomized clinical trial is to to compare the effect of topical rebamipide to topical betamethasone on pain intensity in patients having recurrent oral aphthous ulcers. The main question it aims to answer is : What is the effect of topical Rebamipide mouthwash compared to topical betamethasone mouthwash on pain reduction in patients with oral aphthous ulcers? Participants will will be divided randomly into the two groups and the following outcomes will be measured: Pain associated with oral ulcers Number of oral ulcers Diameter of oral ulcers Healing time of oral ulcers

This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated hemoglobin (HbA1c). Participants will undergo clinical examination, digital panoramic radiographic assessment, and HbA1c measurement.

deleyed fine motor skills are currently considered a as clinical manifestation of autism spectrum disorder, should be assessed due to their high incidence and considerable influence on life quality functional activity

The study will recruit patients having diabetes mellitus; where they will be asked to answer a questionnaire after obtaining an informed consent.

To compare the efficacy of retro discal injection of calcium gluconate-activated PRP versus non-activated PRP in adults with Anterior Disc Displacement with Reduction (ADDWR). Efficacy will be measured by the reduction of symptoms and the restoration of function, specifically targeting the normal Maximum Mouth Opening (MMO) range

The purpose of this study is to compare the effects of the Otago Exercise Program versus Sensorimotor Training on dynamic postural stability and risk of fall in patients with type 2 diabetes mellitus. Participants will be randomly assigned into two equal intervention groups. One group will receive the Otago Exercise Program, while the other group will receive Sensorimotor Training. Both groups will participate in their respective exercise protocols for 8 weeks. Dynamic postural stability and the risk of falling will be assessed before and after the intervention period using standardized physical therapy evaluation tools.

The aim of this study is to evaluate clinically digitally fabricated 3d printed palatal crib versus conventional palatal crib

The goal of this observational study is to assess tibialis posterior muscle morphology in adults with flexible flatfeet. The main question it aims to answer is: Are there differences in tibialis posterior muscle morphology between adults with symptomatic flexible flatfeet, asymptomatic flexible flatfeet, and individuals with normal foot posture? Participants will undergo clinical assessment of foot posture and symptoms and an ultrasound assessment of the tibialis posterior muscle. The study will compare muscle thickness, cross-sectional area, and echo intensity among the three groups.

Lipedema is a chronic condition that mainly affects women and causes abnormal fat accumulation, pain, heaviness, tenderness, swelling, and difficulty with movement, especially in the lower limbs. Liposuction is sometimes used to reduce the abnormal fatty tissue in people with lower-limb lipedema. However, after surgery, patients may still experience swelling, pain, bruising, tissue stiffness, and reduced mobility during recovery. Physiotherapy is an important part of recovery after liposuction for lipedema. It may include compression therapy, manual lymphatic drainage, gentle exercises, walking, skin care, and patient education. These treatments aim to reduce swelling, improve circulation, support tissue healing, and help patients return to daily activities. This study will investigate whether adding Endermologie to a standard physiotherapy program can improve recovery after liposuction for lower-limb lipedema. Endermologie is a non-invasive mechanical massage technique that uses gentle suction and rolling movements to mobilize the skin and soft tissues. It may help support lymphatic drainage, reduce swelling, improve tissue flexibility, and decrease discomfort. Participants in this study will be divided into two groups. One group will receive only standard postoperative physiotherapy. The other group will receive standard postoperative physiotherapy plus Endermologie sessions. The study will compare both groups to see whether Endermologie-assisted physiotherapy provides a better improvement in swelling, pain, tissue stiffness, mobility, and overall functional recovery. The results of this study may help physiotherapists develop more effective rehabilitation protocols for patients recovering from liposuction for lower-limb lipedema.