Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .
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1. Systemic JIA. 2. Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks.
The study will include 60 patients classified as JIA according International League of Associations for Rheumatology ILAR criteria on treatment who will recruited from Rheumatology and Rehabilitation department at Sohag University hospital in addition to 30 healthy individual volunteers without history of any systemic active disease recruited from the community as age and sex matched controls
Case-control
Cross-sectional
complete blood count
Diagnostic testblood test
serum albumin
Diagnostic testblood test
possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis
possibility to detect systemic inflammatory index and its relation to disease activity and risk of flare in juvenile idiopathic arthritis
assessment of activity of disease according to JDAS SCORE
assessment of neutrophils to albumin ratio and its relation to JDAS score activity score
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