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Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy

ConditionPeridontal Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorCairo University

About this trial

This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients above 18 years old.

Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.

Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.

Probing depth ≥6 mm.

Disqualifiers

1. Pregnancy or lactation. 2. Smoking more than 20 cigarettes. 3. Immuno-inflammatory conditions of the skin and oral mucosa 4. systemic conditions affecting bone turnover and periodontal health status (e.g. endocrine and connective tissue diseases, bisphosphonate antiresorptive therapy, gastrointestinal diseases related to nutrition and mineral metabolism) 5. Periodontal or orthodontic treatment at least 6 months before the start of the study 6. Use of anti-inflammatory and antimicrobial agents within 3 months before sampling

Systemically healthy patients.

Patients with an age range between 16 to 80 years.

Patients have a minimum of 20 teeth.

Trial design

Design model

Single group

Treatments tested in this trial

  • Professional mechanical plaque control

    Procedure/Surgery

    thisThe first step in therapy is aimed at guiding behavior change by motivating the patient to undertake successful removal of supragingival dental biofilm and risk factor control and may include the following interventions: * Interventions to improve the effectiveness of oral hygiene \[motivation, instructions (oral hygiene instructions, OHI) * Professional mechanical plaque removal (PMPR), which includes the professional interventions aimed at removing supragingival plaque and calculus, as well as possible plaque-retentive factors that impair oral hygiene practices. * Adjustment of faulty restoration and polishing * The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques.

Treatment groups

22 Participants
are divided into 2 treatment groups
Group A: Healthy ControlNo intervention 0 interventions
Group B: Periodontitis Stage III and IVActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in level of GCF lipoxin A4

Time frame
preoperative, one day, one month and 3 months postoperative

Secondary outcomes

1

Change in level of GCF Protectin

Time frame
preoperative, one day, one month and 3 months postoperative
2

Probing pocket depth (PPD)

Time frame
preoperative, and 3 months postoperative
3

Bleeding On Probing (BOP)

Time frame
preoperative, and 3 months postoperative
4

Plaque index (PI)

Time frame
preoperative, and 3 months postoperative

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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