The goal of this observational study is to investigate the potential association between MMP-9 gene polymorphism and susceptibility to Primary Open Angle Glaucoma development in Egyptian patients The main question it aims to
Men and women older than 30 years
Primary open angle glaucoma as evidenced from characteristic visual field loss and optic disc cupping (POAG group)
Healthy subjects matched by age, sex and ethnicity to the POAG patients group (control group)
Exfoliation glaucoma, pigmentary glaucoma
History of acute angle closure
Patients with Primary Open Angle Glaucoma in Department of ophthalmology in Sohag University Hospitals and healthy controls of matched age and sex
Case-control
Cross-sectional
genotyping assay by polymerase chain reaction
GeneticBlood sample will be obtained from all participants by withdrawing 3 mL of blood via venipuncture in ethylenediaminetetraacetic acid tube. Thereafter, DNA extraction will be obtained after centrifugation to be used for genotyping assay of MMP-9 gene with polymerase chain reaction
Matrix metalloproteinase-9 gene polymorphism
Matrix metalloproteinase-9 gene polymorphism by polymerase chain reaction
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